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Diazepam is N-demethylated by CYP3A4 and 2C19 on the Energetic metabolite N-desmethyldiazepam, and is particularly hydroxylated by CYP3A4 for the active metabolite temazepam. N-desmethyldiazepam and temazepam are equally even more metabolized to oxazepam. Temazepam and oxazepam are mainly eliminated by glucuronidation.Psychiatric and paradoxical re